医学
感染性休克
耐火材料(行星科学)
重症监护医学
病危
严重败血症
败血症
休克(循环)
介绍
干预(咨询)
临床试验
内科学
家庭医学
天体生物学
精神科
物理
作者
Prashanth Nandhabalan,Nicholas Ioannou,Christopher I. S. Meadows,Duncan Wyncoll
出处
期刊:Critical Care
[Springer Nature]
日期:2018-09-19
卷期号:22 (1)
被引量:47
标识
DOI:10.1186/s13054-018-2144-4
摘要
Despite timely intervention, there exists a small subgroup of patients with septic shock who develop progressive multi-organ failure. Seemingly refractory to conventional therapy, they exhibit a very high mortality. Such patients are often poorly represented in large clinical trials. Consequently, good evidence for effective treatment strategies is lacking. In this article, we describe a pragmatic, multi-faceted approach to managing patients with refractory septic shock based on our experience of toxin-mediated sepsis in a specialist referral centre. Many components of this strategy are inexpensive and widely accessible, and so may offer an opportunity to improve outcomes in these critically ill patients.
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