Graphitic Carbon Electrodes on Flexible Substrate for Neural Applications Entirely Fabricated Using Infrared Nanosecond Laser Technology

材料科学 电极 拉曼光谱 碳化 玻璃碳 激光器 基质(水族馆) 碳纳米管 纳米技术 纳秒 光电子学 电化学 循环伏安法 化学 复合材料 光学 扫描电子显微镜 物理 海洋学 物理化学 地质学
作者
Maria Vomero,Ana Cláudia Costa de Oliveira,Danesh Ashouri Vajari,Max Eickenscheidt,Thomas Stieglitz
出处
期刊:Scientific Reports [Nature Portfolio]
卷期号:8 (1) 被引量:29
标识
DOI:10.1038/s41598-018-33083-w
摘要

Abstract Neural interfaces for neuroscientific research are nowadays mainly manufactured using standard microsystems engineering technologies which are incompatible with the integration of carbon as electrode material. In this work, we investigate a new method to fabricate graphitic carbon electrode arrays on flexible substrates. The devices were manufactured using infrared nanosecond laser technology for both patterning all components and carbonizing the electrode sites. Two laser pulse repetition frequencies were used for carbonization with the aim of finding the optimum. Prototypes of the devices were evaluated in vitro in 30 mM hydrogen peroxide to mimic the post-surgery oxidative environment. The electrodes were subjected to 10 million biphasic pulses (39.5 μC/cm 2 ) to measure their stability under electrical stress. Their biosensing capabilities were evaluated in different concentrations of dopamine in phosphate buffered saline solution. Raman spectroscopy and x-ray photoelectron spectroscopy analysis show that the atomic percentage of graphitic carbon in the manufactured electrodes reaches the remarkable value of 75%. Results prove that the infrared nanosecond laser yields activated graphite electrodes that are conductive, non-cytotoxic and electrochemically inert. Their comprehensive assessment indicates that our laser-induced carbon electrodes are suitable for future transfer into in vivo studies, including neural recordings, stimulation and neurotransmitters detection.

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