Sepsis-induced thrombus formation and cell-specific HIFs

•The impact of cell-specific and hypoxia-responsive signaling pathways on sepsis-induced thrombus formation is unclear •Evidence for a role of cell-specific HIFs in sepsis-induced thrombosis could lead to the identification of a novel therapeutic target •Nanoparticle-based drug delivery strategies could be used in the treatment of sepsis-induced thrombosis