Efficient Synthesis of Unsymmetrical Heteroaryl Ethers by a Transition Metal‐Free CO Cross‐Coupling Reaction of Activated and Unactivated Heteroaryl Chlorides with Alcohols and Phenols

Abstract By optimizing the reaction conditions via a careful screening of the bases and solvents, we developed an efficient transition metal‐free method for CO cross‐coupling of activated and unactivated heteroaryl chlorides with primary and secondary alcohols and phenols, providing a simple, efficient, and practical method for synthesis of the useful unsymmetrical heteroaryl alkyl and heteroaryl aryl ethers.