Self‐Indicative Gold Nanozyme for H2O2 and Glucose Sensing

Abstract In addition to superior enzyme‐mimicking abilities, nanozymes also have intrinsic physicochemical properties. Integrating the enzyme‐like activities and tunable physicochemical properties into a single nanoparticle is a promising strategy for versatile nanozyme design and application. Herein, a composite nanozyme in which Au nanoparticles are encapsulated by Au nanoclusters (AuNP@AuNCs) is presented. By integrating the peroxidase‐mimicking ability of fluorescent Au NCs with the glucose oxidase‐like activity of Au NPs, the composite nanozyme realized cascade assay of glucose without the aid of external indicators. Compared to traditional multistep colorimetric methods, the analytical process was highly simplified by using the self‐responsive nanozyme. This synthetic strategy provided valuable insights into exploring talented nanozymes for sensing diverse targets.