离子迁移光谱法
化学
质谱法
离子迁移谱-质谱
离子
分析物
漂移管,漂移管
分析化学(期刊)
色谱法
电喷雾电离
有机化学
质谱中的样品制备
作者
Lourdes Arce,Janneth Gallegos,Rocío Garrido‐Delgado,L. M. Medina,Stepanie Sielemann,Thomas Wortelmann
出处
期刊:Current metabolomics
[Bentham Science]
日期:2015-03-09
卷期号:2 (4): 264-271
被引量:27
标识
DOI:10.2174/2213235x03999150212102944
摘要
Linear Ion Mobility Spectrometry (IMS) is a vanguard analytical technique for the determination of volatile and semi-volatile compounds, thanks to the gas-phase separation of the different ions under a weak electric field at atmospheric pressure. The ions migrate through a drift tube with defined length. Monitoring of the ion current reveals the ion drift time. The drift time correlates to the specific ion-mobility, a function of the ion mass, charge and collision cross section with the ambient gas. In this article, IMS, a technology initially developed for detecting traces of explosive and narcotic residues, as well as chemical warfare agents will be presented to meet the special requirements of metabolomics analysis. With the right sampling approach, IMS enables the detection of a wide number of compounds from different chemistry families, including alcohols, aldehydes, aromatics, amines, esters and ketones, among others, even from most complicated and problematic matrices. The selectivity of IMS can be improved by coupling to Gas Chromatography or Mass Spectrometry in order to improve separation or detection of analytes respectively. Other types of IMS such as, Travelling Wave IMS (TWIMS) and High Field Asymmetric Waveform IMS (FAIMS) have also enhanced the analytical possibilities of this technique. Keywords: Ion mobility spectrometry, volatile, and semi-volatile compounds, foodomics.
科研通智能强力驱动
Strongly Powered by AbleSci AI