Development of the Study of Interaction Between Metal Ions and Serum Albumin

The study of interaction between metal ions and proteins is a new frontier of chemistry and life science. About the interaction between metal ions and serum albumin is given. Methods frequently used in the study, such as ultraviolet spectroscopy, fluorescence spectroscopy and equilibrium dialysis, are briefly introduced. According to the reported results available nowadays, binding sites of metal ions on protein, space configuration, binding number and stability constants of metal-protein complex are summarized, and the strong binding sites between metal ions and serum albumin are classified. At last, the existing problems and studying tendency of this field are discussed.