Inhibition of STAT4 Activation by Lisofylline Is Associated with the Protection of Autoimmune Diabetes

A bstract : We investigated the signal transduction pathway of IL‐12 and showed that lisofylline (LSF) inhibited the signal transducer and activator of transcription factor‐4 (STAT4) activation. Interruption of IL‐12‐mediated STAT4 activation prevented autoimmune diabetes in NOD mice.