组蛋白
表观遗传学
生物
癌变
表观遗传学
遗传学
DNA甲基化
癌症
计算生物学
癌症研究
DNA
基因
基因表达
作者
Ping Chi,C. David Allis,Gang Greg Wang
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2010-07-01
卷期号:10 (7): 457-469
被引量:975
摘要
Post-translational modification of histones provides an important regulatory platform for processes such as gene transcription and DNA damage repair. It has become increasingly apparent that the misregulation of histone modification, which is caused by the deregulation of factors that mediate the modification installation, removal and/or interpretation, actively contributes to human cancer. In this Review, we summarize recent advances in understanding the interpretation of certain histone methylations by plant homeodomain finger-containing proteins, and how misreading, miswriting and mis-erasing of histone methylation marks can be associated with oncogenesis and progression. These observations provide us with a greater mechanistic understanding of epigenetic alterations in human cancers and might also help direct new therapeutic interventions in the future.
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