Two principal modes of Northern Hemisphere (NH) wintertime blocking variability are identified to examine the possible relationships between regional blocking activities and to understand how they are linked. The first mode of NH blocking variability is characterized by regional blocking activities including the North Pacific (PA), Greenland, European, and Ural-Siberian regions. There exists dominant PA blocking associated with the negative North Pacific Oscillation (NPO) pattern. The second mode shows a zonally dipole pattern between PA and North Atlantic (AT) blockings. It is more related to AT blocking, such that there is strong coupling with the negative North Atlantic Oscillation (NAO) pattern. Correlation analysis with major climate variability patterns revealed that both the NPO and NAO may modulate the two leading modes of NH blocking variability. Also, the NPO and Arctic Oscillation (AO) can simultaneously be associated with the blocking occurrence over both the PA and AT basins. The negative phase of the NPO (AO) is favorable for the in- phase (out-of-phase) relationship between west of (south of) PA and south of (west of) AT blocking sectors. This occurs because NH blocking occurrence is dependent on the phase of the AO, especially in the negative NPO pattern. If the NPO and AO are in phase (out of phase), NH blocking occurrence is more enhanced (weakened), in particular, having higher frequency over the Pacific and higher (lower) frequency over the Northwest Atlantic.