并行传输
紧密连接
生物制药
吸收(声学)
细胞生物学
药品
功能(生物学)
克洛丹
势垒函数
化学
生物物理学
药理学
医学
生物
材料科学
生物化学
遗传学
磁导率
膜
复合材料
出处
期刊:Critical Reviews in Therapeutic Drug Carrier Systems
[Begell House Inc.]
日期:2005-01-01
卷期号:22 (4): 331-418
被引量:14
标识
DOI:10.1615/critrevtherdrugcarriersyst.v22.i4.10
摘要
Tight junctions (TJs) located between adjacent epithelial cells restrict the movement of solutes, ions, and even water. Restriction of macromolecules by TJ structures impedes one potential route of absorption for biopharmaceutical drugs, a route known as the paracellular pathway. It is anticipated that an improved understanding of TJ structure and cellular mechanisms that regulate its function will lead to successful strategies for improved transmucosal drug absorption through the paracellular pathway. Based upon clinical correlations between TJ dysfunction and several disease states, any approach to modify TJ integrity to enhance drug absorption in this way must be tempered by an appreciation of potential safety concerns that might develop through sustained or repeated TJ alterations. This review describes a current understanding of epithelial TJ organization and examines potential methods and implications for regulated modification of TJ function for the enhanced uptake of drugs without detrimental clinical outcomes.
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