Validation of Partin Tables and Development of a Preoperative Nomogram for Japanese Patients With Clinically Localized Prostate Cancer Using 2005 International Society of Urological Pathology Consensus on Gleason Grading: Data From the Clinicopathological Research Group for Localized Prostate Cancer

No AccessJournal of UrologyAdult Urology1 Sep 2008Validation of Partin Tables and Development of a Preoperative Nomogram for Japanese Patients With Clinically Localized Prostate Cancer Using 2005 International Society of Urological Pathology Consensus on Gleason Grading: Data From the Clinicopathological Research Group for Localized Prostate Cancer Seiji Naito, Kentaro Kuroiwa, Naoko Kinukawa, Ken Goto, Hirofumi Koga, Osamu Ogawa, Masaru Murai, Taizo Shiraishi, and Clinicopathological Research Group for Localized Prostate Cancer Investigators Seiji NaitoSeiji Naito Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan , Kentaro KuroiwaKentaro Kuroiwa Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan , Naoko KinukawaNaoko Kinukawa Department of Medical Information Science, Kyushu University Hospital, Fukuoka, Japan , Ken GotoKen Goto Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan , Hirofumi KogaHirofumi Koga Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan , Osamu OgawaOsamu Ogawa Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan , Masaru MuraiMasaru Murai Department of Urology, Keio University School of Medicine, Tokyo, Japan , Taizo ShiraishiTaizo Shiraishi Department of Pathology, Mie University School of Medicine, Mie, Japan , and Clinicopathological Research Group for Localized Prostate Cancer Investigators View All Author Informationhttps://doi.org/10.1016/j.juro.2008.05.047AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We validated the 2001 Partin tables and developed an original nomogram for Japanese patients using the 2005 International Society of Urological Pathology consensus on Gleason grading. Materials and Methods: Prostatectomy specimens from 1,188 Japanese men who underwent radical prostatectomy for clinically localized prostate cancer (cT1-2) between 1997 and 2005 were analyzed. Polychotomous logistic regression analysis was used to construct a nomogram to predict final pathological stage (organ confined disease, extraprostatic extension, seminal vesicle invasion and lymph node involvement) from 3 variables, including serum prostate specific antigen, clinical stage and biopsy Gleason score. The area under the ROC curve was used to compare the new nomogram with the Partin tables. Results: Preoperative serum prostate specific antigen and biopsy Gleason score were higher in the Japanese cohort than in the Partin cohort. The distribution of clinical and final pathological stages was similar in the 2 cohorts. The AUC for predicting organ confined disease was 0.699 and 0.717 for data applied to the Partin tables and to the new nomogram, respectively. The AUC for predicting lymph node involvement was 0.793 and 0.863, respectively. Conclusions: To our knowledge this is the first preoperative nomogram developed for clinically localized prostate cancer in Japanese patients. Although the new nomogram predicted the pathological stage of prostate cancer in Japanese patients more accurately than the Partin tables, it did not satisfactorily predict organ confined disease. However, other predictive variables, such as more detailed pathological features of biopsy specimens or magnetic resonance imaging, may further improve prediction accuracy. References 1 : Cancer control with radical prostatectomy alone in 1,000 consecutive patients. J Urol2002; 167: 528. Link, Google Scholar 2 : Contemporary update of prostate cancer staging nomograms (Partin Tables) for the new millennium. Urology2001; 58: 843. Google Scholar 3 : The use of prostate specific antigen, clinical stage and Gleason score to predict pathological stage in men with localized prostate cancer. J Urol1993; 150: 110. Link, Google Scholar 4 : Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer: A multi-institutional update. JAMA1997; 277: 1445. Google Scholar 5 : Serum prostate-specific antigen in a community-based population of healthy Japanese men: lower values than for similarly aged white men. Br J Urol1995; 75: 347. Google Scholar 6 : The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol2005; 29: 1228. Google Scholar 7 : Correlation of clinical stage, serum prostatic acid phosphatase and preoperative Gleason grade with final pathological stage in 275 patients with clinically localized adenocarcinoma of the prostate. J Urol1987; 138: 92. Link, Google Scholar 8 : Comparison of prostate-specific antigen and hormone levels among men in Singapore and the United States. Cancer Epidemiol Biomarkers Prev2005; 14: 1692. Google Scholar 9 : How well does the Partin nomogram predict pathological stage after radical prostatectomy in a community based population?: Results of the cancer of the prostate strategic urological research endeavor. J Urol2002; 167: 1653. Link, Google Scholar 10 : Validation of Partin tables for predicting pathological stage of clinically localized prostate cancer. J Urol2000; 164: 1591. Link, Google Scholar 11 : Can predictive models for prostate cancer patients derived in the United States of America be utilized in European patients?: A validation study of the Partin tables. Eur Urol2003; 43: 6. Google Scholar 12 : Comparison of accuracy between the Partin tables of 1997 and 2001 to predict final pathological stage in clinically localized prostate cancer. J Urol2004; 171: 177. Link, Google Scholar 13 : Validation of 2001 Partin tables in Turkey: a multicenter study. Eur Urol2005; 47: 185. Google Scholar 14 : International validation of a preoperative nomogram for prostate cancer recurrence after radical prostatectomy. J Clin Oncol2002; 20: 3206. Google Scholar 15 : Impact of a multidisciplinary continuous quality improvement program on the positive surgical margin rate after laparoscopic radical prostatectomy. Eur Urol2006; 49: 853. Google Scholar 16 : A study of pretreatment nomograms to predict pathological stage and biochemical recurrence after radical prostatectomy for clinically resectable prostate cancer in Japanese men. Jpn J Clin Oncol2001; 31: 74. Google Scholar 17 : Updated protocol for the examination of specimens from patients with carcinomas of the prostate gland: a basis for checklists: Cancer Committee. Arch Pathol Lab Med2000; 124: 1034. Google Scholar 18 : Current practice of Gleason grading among genitourinary pathologists. Hum Pathol2005; 36: 5. Google Scholar 19 : Prostate cancer and the Will Rogers phenomenon. J Natl Cancer Inst2005; 97: 1248. Google Scholar 20 : The Will Rogers phenomenon: Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer. N Engl J Med1985; 312: 1604. Google Scholar © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 180Issue 3September 2008Page: 904-910 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordsprostateprostatic neoplasmsJapannomogramsprostatectomyMetrics Author Information Seiji Naito Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan More articles by this author Kentaro Kuroiwa Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan More articles by this author Naoko Kinukawa Department of Medical Information Science, Kyushu University Hospital, Fukuoka, Japan More articles by this author Ken Goto Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan More articles by this author Hirofumi Koga Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan More articles by this author Osamu Ogawa Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan More articles by this author Masaru Murai Department of Urology, Keio University School of Medicine, Tokyo, Japan More articles by this author Taizo Shiraishi Department of Pathology, Mie University School of Medicine, Mie, Japan More articles by this author Clinicopathological Research Group for Localized Prostate Cancer Investigators More articles by this author Expand All Advertisement PDF downloadLoading ...