审查(临床试验)
估计员
统计
逆概率加权
非参数统计
置信区间
接收机工作特性
加权
事件(粒子物理)
反概率
计量经济学
计算机科学
Kaplan-Meier估计量
数学
医学
贝叶斯概率
物理
放射科
量子力学
后验概率
作者
Paul Blanche,Jean‐François Dartigues,Hélène Jacqmin‐Gadda
摘要
The area under the time-dependent ROC curve (AUC) may be used to quantify the ability of a marker to predict the onset of a clinical outcome in the future. For survival analysis with competing risks, two alternative definitions of the specificity may be proposed depending of the way to deal with subjects who undergo the competing events. In this work, we propose nonparametric inverse probability of censoring weighting estimators of the AUC corresponding to these two definitions, and we study their asymptotic properties. We derive confidence intervals and test statistics for the equality of the AUCs obtained with two markers measured on the same subjects. A simulation study is performed to investigate the finite sample behaviour of the test and the confidence intervals. The method is applied to the French cohort PAQUID to compare the abilities of two psychometric tests to predict dementia onset in the elderly accounting for death without dementia competing risk. The 'timeROC' R package is provided to make the methodology easily usable.
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