医学
血栓形成
血栓性
儿科
重症监护医学
流行病学
静脉血栓形成
败血症
内科学
作者
Rukhmi Bhat,Paul Monagle
出处
期刊:Archives of Disease in Childhood-fetal and Neonatal Edition
[BMJ]
日期:2012-05-06
卷期号:97 (6): F423-F428
被引量:32
标识
DOI:10.1136/archdischild-2011-301142
摘要
In paediatrics, sick preterm infants are at highest risk of developing thrombotic complications. Haemostasis is in a fine balance in the neonatal period, despite age-related differences in coagulation proteins. However, both inherited and acquired risk factors can disrupt this balance and can lead to thrombosis. Important risk factors are sepsis, asphyxia, dehydration, central venous lines and inherited and acquired thrombophilia. Among various treatment modalities, anticoagulation is primarily used in the management of thrombosis. Different agents, dosages and durations of treatment in this age group are extrapolated from adult data. The article reviews the epidemiology, pathophysiology, risk factors, diagnosis and treatment of thrombotic disorders in preterm infants.
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