生物素化
链霉亲和素
紫杉醇
生物素
组合化学
微管
化学
衍生工具(金融)
体外
生物物理学
生物化学
细胞生物学
生物
遗传学
化疗
金融经济学
经济
作者
Lev Lis,Mary Ann Smart,Anna Łuchniak,Mohan L. Gupta,Vadim J. Gurvich
摘要
A biotinylated paclitaxel derivative with an extra-long chain (LC-LC-biotin) spacer arm was synthesized using an improved synthetic reaction sequence. The biotinylated paclitaxel analogue retained excellent microtubule stabilizing activity in vitro. Furthermore, it was shown that this analogue can simultaneously engage streptavidin and the binding site on microtubules, making it suitable for localization studies or for the attachment of paclitaxel to solid substrates via a streptavidin linkage.
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