Electrochemical oxidation behavior of colchicine on a graphene oxide-Nafion composite film modified glassy carbon electrode

An electrochemical sensor, based on a graphene oxide (GO)-Nafion composite film modified glassy carbon electrode (GCE), was developed and used for detection of trace amounts of colchicine. Owing to the large surface area, good conductivity of GO and good affinity of Nafion, the sensor exhibited excellent electrocatalytic activity for the oxidation of colchicine, displaying a wide linear response from 5.0 × 10−8 to 2.0 × 10−5 mol L−1 and a low detection limit of 1.5 × 10−8 mol L−1 in 0.1 mol L−1H2SO4 solution. And this modified electrode exhibited a superior immunity from epinephrine, dopamine and ascorbic acid interference. The method was also applied successfully to detect colchicine in medicinal tablets.