巴比妥酸
喹啉酸
犬尿氨酸途径
神经保护
犬尿氨酸
致电离效应
药理学
运动障碍
帕金森病
谷氨酸受体
神经科学
化学
医学
生物
生物化学
色氨酸
疾病
受体
氨基酸
内科学
作者
Nikoletta Szabó,Zsigmond Tamás Kincses,József Toldi,László Vécsei
标识
DOI:10.1016/j.jns.2011.07.021
摘要
Parkinson's disease (PD) is one of the most common disabling neurodegenerative diseases. Although several therapeutic approaches are available, there are two major unresolved issues: the lack of proved neuroprotective therapy and the treatment of L-dopa-induced motor complications. In the brain, 90% of the tryptophan is metabolized in the kynurenine pathway. Some of the intermediates, such as quinolinic acid and 3-hydroxy kynurenine, are neurotoxic, while others, such as kynurenic acid, are putative intrinsic neuroprotective compounds, mainly by acting as endogenous antagonists of ionotropic excitatory amino acid receptors. Alterations in the kynurenine pathway have been demonstrated in PD. Preclinical data suggest that intervention in the kynurenine pathway may result in neuroprotection and may alleviate L-dopa-induced dyskinesia. There are two alternative approaches for such intervention: the use of kynurenic acid analogues or pro-drugs, or modulation of the activities of the intrinsic enzymes of the pathway.
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