医学
多态性(计算机科学)
抗精神病药
内科学
非定型抗精神病薬
遗传学
内分泌学
基因
等位基因
精神科
生物
精神分裂症(面向对象编程)
作者
Gavin P. Reynolds,Zhi‐Jun Zhang,Xiaobin Zhang
出处
期刊:The Lancet
[Elsevier]
日期:2002-06-01
卷期号:359 (9323): 2086-2087
被引量:402
标识
DOI:10.1016/s0140-6736(02)08913-4
摘要
A side-effect of treatment with antipsychotic drugs for schizophrenia is increased body fat, which leads to further morbidity and poor adherence to treatment. The 5-hydroxytryptamine 2C receptor (5-HT2C) has been associated with this effect; we aimed to establish whether a genetic polymorphism of the promoter region of this receptor affects weight gain after drug treatment in first-episode patients with schizophrenia. We noted significantly less weight gain in patients with the −759T variant allele (p=0·0003) than in those without this allele, who were more likely to have substantial (>7%) weight gain (p=0·002). We have identified a genetic factor that is associated with antipsychotic drug-induced weight gain.
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