材料科学
膜
共聚物
相位反转
氟化物
生物污染
聚丙烯酸
化学工程
凝血酶时间
阿加曲班
部分凝血活酶时间
高分子化学
聚合物
凝结
复合材料
凝血酶
无机化学
化学
免疫学
工程类
精神科
血小板
生物
生物化学
心理学
作者
Rui Xu,Qianqian Feng,Yang He,Fanyong Yan,Li Chen,Yiping Zhao
摘要
The present work aims to improve the antifouling properties and anticoagulation of poly(vinylidene fluoride) (PVDF) membrane by dual modification. An amphiphilic copolymer of PVDF-g-(polyacryloylmorpholine-(polyacrylic acid)) [PVDF-g-(PACMO-PAA)] was first prepared by the free radical copolymerization. Then argatroban, a commonly used anticoagulant, was successfully grafted to PVDF-g-(PACMO-PAA). Finally the obtained copolymer was casted into a flat membrane via immersion phase inversion. The as-prepared copolymer membranes show improved hydrophilicity, higher water flux and lower protein adsorption. Moreover, the hemolysis and coagulation tests for the dual functionalized PVDF membrane exhibit decreased hemolysis ratio, with prolonged plasma recalcification time, activated partial thromboplastin time and thrombin time. PVDF membrane incorporating PACMO and AG reveals an improved hemocompatibility, which has a good potential to be used in blood purification. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 178-188, 2017.
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