不利影响
免疫系统
医学
试验药物
重症监护医学
临床试验
免疫检查点
生物信息学
免疫疗法
药理学
免疫学
内科学
生物
作者
Ryan J. Sullivan,Jeffrey S. Weber
标识
DOI:10.1038/s41573-021-00259-5
摘要
The immune-related adverse events associated with treatment with immune checkpoint inhibitors result in significant morbidity for patients as well as considerable cost to the health-care system, and can limit the use of these beneficial drugs. Understanding the mechanisms of these side effects and how they can be separated from the antitumour effects of immune checkpoint inhibitors, as well as identifying biomarkers that predict the development of immune-related toxicities, will facilitate the conduct of trials to limit their onset and improve patient outcomes. In this Review, we discuss the different types of immune-related adverse events and how their treatment and identification of possible predictive biomarkers may shed light on their mechanisms, and describe possible strategies and targets for prophylactic and therapeutic intervention to mitigate them.
科研通智能强力驱动
Strongly Powered by AbleSci AI