Injectable Double‐Crosslinked Adhesive Hydrogels with High Mechanical Resilience and Effective Energy Dissipation for Joint Wound Treatment

材料科学 自愈水凝胶 胶粘剂 粘附 组织粘连 复合材料 弹性(材料科学) 壳聚糖 伤口愈合 生物医学工程 化学工程 高分子化学 图层(电子) 外科 医学 工程类
作者
Kai Chen,Zihan Wu,Yutong Liu,Yuan Yuan,Changsheng Liu
出处
期刊:Advanced Functional Materials [Wiley]
卷期号:32 (12) 被引量:145
标识
DOI:10.1002/adfm.202109687
摘要

Abstract Due to the moist environment and inevitable movement, efficient wound closure and healing of vulnerable joint skin remains a great challenge. Herein, a poly(γ‐glutamic acid)‐crosslinked amino‐functionalized PEGylated poly(glycerol sebacate) (γ‐PGA/PEGS‐NH 2 ) adhesive hydrogel is reported. PEGS‐NH 2 and γ‐PGA not only forms covalent amide bonds with biological tissue surfaces to achieve strong moist adhesion but also establishes a stable chemically crosslinked network in bulk hydrogels to resist deformation. Furthermore, bioinspired gallic acid‐modified chitosan (CS‐GA) is introduced to enhance moist adhesion via multiple hydrogen bonds and establish a dynamic physically crosslinked network to dissipate energy. Consequently, this adhesive hydrogel strongly adheres to moist biological tissue, showing an adhesion six times higher than that of fibrin glue and comparable to that of strong cyanoacrylate glue. Moreover, benefiting from high mechanical resilience and effective energy dissipation, 200 cycles of loading–unloading mechanical tests conducted under an adhesive state and a full‐thickness rat skin incision model applied on a dynamic nape further confirmed the desirable dynamic tissue adhesion and wound healing performance. Combining the above ideal features with their good injectability and shape‐adaptability to complex contours, such adhesive hydrogels are demonstrated to be promising candidates for joint wound closure and healing in moist and dynamic physiological environment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
坚果发布了新的文献求助10
1秒前
xxx应助马敬丽采纳,获得10
1秒前
1秒前
STAR完成签到,获得积分10
1秒前
2秒前
斯文败类应助宓广缘采纳,获得30
2秒前
2秒前
2秒前
李爱国应助大端采纳,获得10
2秒前
2秒前
mingjie完成签到,获得积分10
3秒前
量子星尘发布了新的文献求助10
3秒前
3秒前
5秒前
pluto应助万万想到了采纳,获得10
5秒前
无花果应助含糊的鱼采纳,获得10
5秒前
7秒前
科研不通完成签到,获得积分10
7秒前
7秒前
maliang666完成签到,获得积分10
7秒前
王先森给王先森的求助进行了留言
7秒前
Lemonade完成签到,获得积分10
8秒前
虚心的芹发布了新的文献求助10
8秒前
8秒前
嗯呐发布了新的文献求助10
8秒前
景行行止发布了新的文献求助10
9秒前
lilinju完成签到,获得积分10
9秒前
传奇3应助PanCiro采纳,获得20
9秒前
9秒前
陌上花开发布了新的文献求助10
10秒前
smottom应助炙热的羽毛采纳,获得10
10秒前
11秒前
伊丽莎白完成签到,获得积分10
11秒前
11秒前
12秒前
爆米花应助momo采纳,获得10
12秒前
大个应助UltraYuan采纳,获得50
12秒前
领导范儿应助景行行止采纳,获得10
14秒前
14秒前
热情大树发布了新的文献求助10
14秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971091
求助须知:如何正确求助?哪些是违规求助? 3515797
关于积分的说明 11179488
捐赠科研通 3250872
什么是DOI,文献DOI怎么找? 1795536
邀请新用户注册赠送积分活动 875891
科研通“疑难数据库(出版商)”最低求助积分说明 805207