免疫系统
间质细胞
炎症
免疫学
间充质干细胞
生物
成纤维细胞
发病机制
关节炎
细胞生物学
医学
癌症研究
遗传学
细胞培养
作者
Jasna Friščić,Markus Hoffmann
标识
DOI:10.1016/j.coi.2021.10.006
摘要
In the last fifteen years it has become apparent that tissue-resident mesenchymal cells such as fibroblasts, which are the structural elements of all organs, play a cardinal role in the pathology of immune-mediated inflammatory diseases. We now know that all fibroblasts originate from universal pan-organ cellular ancestors and that they are diversified into more specific subsets according to the functional needs of their home tissue-and its activation state. In arthritis, a plethora of activated joint-resident and migrating fibroblast types have been recently described that are central for pathogenesis and persistence of inflammatory joint-disease. Here we provide a current overview on the multiple inflammatory and immune-related functions of fibroblasts and how they could be curbed to induce long-lasting abatement of disease.
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