替代(逻辑)
药物化学
取代反应
亲核细胞
组合化学
作者
Arun Raj Kizhakkayil Mangadan,Ji Liu,Aaron Aponick
标识
DOI:10.1002/anie.202108336
摘要
Abstract Asymmetric allylic alkylation (AAA) is a powerful method for the formation of highly useful, non‐racemic allylic compounds. Here we present a complementary enantioselective process that generates allylic lactones via π‐acid catalysis. More specifically, a catalytic enantioselective dehydrative lactonization of allylic alcohols using a novel Pd II ‐catalyst containing the imidazole‐based P , N ‐ligand ( S )‐StackPhos is reported. The high‐yielding reactions are operationally simple to perform with enantioselectivities up to 99 % ee . This strategy facilitates the replacement of a poor leaving group with what would ostensibly be a better leaving group in the product avoiding complications arising from racemization by equilibration.
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