An innovative layer-by-layer coated titanium hydroxide-(gentamicin-polydopamine) as a hybrid drug delivery platform

This work developed an innovative hybrid inorganic-organic-drug multilayer coating process to improve drug release time from the coating surface. The feasibility of chemical in situ self-polymerization of polydopamine (PDA) layer on nanostructured titanium hydroxide (TiOH) surface was investigated. The drug delivery platform containing gentamicin (Gent) was obtained and compared with two different layer-by-layer coating methods, both non-simultaneous and simultaneous. Through the XRD, FTIR, and EDS, the main components of the pre-treated surface were identified as nanostructured TiOH. The surface morphology, chemical composition, drug-release kinetics, and zeta potentials of the obtained multilayers were investigated by FESEM, SEM, EDS, FTIR, UV–Vis, and Zetasizer. The multilayer hybrid drug delivery platforms demonstrated a prolonged drug release and in vitro inhibitory effect on the growth of the S. aureus . In addition, the bioactivity of the coatings was examined after the bio-mineralization process in the simulated body fluid. In conclusion, the developed TiOH-(Gent-PDA) surface coating system shows great potential for improving self-antibacterial performance, bioactivity, and longevity of Ti-based biomaterials. • İnnovative hybrid layered coatings have been developed to improve drug release time. • Drug-loaded coatings were produced using both simultaneous and asynchronous methods. • Drug delivery platform demonstrated antimicrobial effect and bioactivity.