类有机物
自愈水凝胶
再生医学
生物相容性
纳米技术
细胞外基质
组织工程
干细胞
化学
生物医学工程
细胞生物学
生物
材料科学
医学
有机化学
作者
Panqin Ma,Ying Chen,Xiyu Lai,Jie Zheng,Enyi Ye,Xian Jun Loh,Yi Zhao,Bhav Harshad Parikh,Xinyi Su,Ming You,Yun‐Long Wu,Yupeng Liu
标识
DOI:10.1002/mabi.202100191
摘要
Human organoids mimic the physiology and tissue architecture of organs and are of great significance for promoting the study of human diseases. Traditionally, organoid cultures rely predominantly on animal or tumor-derived extracellular matrix (ECM), resulting in poor reproducibility. This limits their utility in for large-scale drug screening and application for regenerative medicine. Recently, synthetic polymeric hydrogels, with high biocompatibility and biodegradability, stability, uniformity of compositions, and high throughput properties, have emerged as potential materials for achieving 3D architectures for organoid cultures. Compared to conventional animal or tumor-derived organoids, these newly engineered hydrogel-based organoids more closely resemble human organs, as they are able to mimic native structural and functional properties observed in-situ. In this review, recent developments in hydrogel-based organoid culture will be summarized, emergent hydrogel technology will be highlighted, and future challenges in applying them to organoid culture will be discussed.
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