功能(生物学)
神经科学
心理学
脑功能
生物
进化生物学
作者
Michael Nair‐Collins,Ari R. Joffe
出处
期刊:Handbook of Clinical Neurology
[Elsevier BV]
日期:2021-01-01
卷期号:: 433-446
被引量:14
标识
DOI:10.1016/b978-0-12-819973-2.00029-0
摘要
Some patients who have been diagnosed as “dead by neurologic criteria” continue to exhibit certain brain functions, most commonly, neuroendocrine functions. In this chapter, we review the pathophysiology of brain death that can lead either to neuroendocrine failure or to preserved neuroendocrine functioning. We review the evidence on continued hypothalamic functioning in patients who have been declared “brain dead,” examine potential mechanisms that would explain these findings, and discuss how these findings create additional confounds for brain death testing. We conclude by reviewing the evidence for the management of hypothalamic–pituitary failure in the setting of brain death and organ transplantation.
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