急性呼吸窘迫综合征
医学
免疫学
炎症
慢性阻塞性肺病
趋化因子
特发性肺纤维化
肺
背景(考古学)
免疫系统
促炎细胞因子
发病机制
生物
内科学
古生物学
作者
Jae Won Lee,Chun Wang,Hee Jae Lee,Jeong Ki Min,Seong‐Man Kim,Ji‐Yun Seo,Ki Hoon Ahn,Sei‐Ryang Oh
出处
期刊:Cells
[MDPI AG]
日期:2021-04-14
卷期号:10 (4): 897-897
被引量:92
标识
DOI:10.3390/cells10040897
摘要
Macrophages play an important role in the innate and adaptive immune responses of organ systems, including the lungs, to particles and pathogens. Cumulative results show that macrophages contribute to the development and progression of acute or chronic inflammatory responses through the secretion of inflammatory cytokines/chemokines and the activation of transcription factors in the pathogenesis of inflammatory lung diseases, such as acute lung injury (ALI), acute respiratory distress syndrome (ARDS), ARDS related to COVID-19 (coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)), allergic asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF). This review summarizes the functions of macrophages and their associated underlying mechanisms in the development of ALI, ARDS, COVID-19-related ARDS, allergic asthma, COPD, and IPF and briefly introduces the acute and chronic experimental animal models. Thus, this review suggests an effective therapeutic approach that focuses on the regulation of macrophage function in the context of inflammatory lung diseases.
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