电梯
运输机
背景(考古学)
生物物理学
机制(生物学)
转运蛋白
基质(水族馆)
膜
底物特异性
细胞生物学
生物
化学
生物化学
材料科学
基因
酶
物理
复合材料
古生物学
量子力学
生态学
标识
DOI:10.1016/j.tibs.2021.03.007
摘要
Elevator-type transporters are a group of proteins translocating nutrients and metabolites across cell membranes. Despite structural and functional differences, elevator-type transporters use a common mechanism of substrate translocation via reversible movements of a mobile core domain (the elevator), which includes the substrate binding site, along a rigid scaffold domain, stably anchored in the plasma membrane. How substrate specificity is determined in elevator transporters remains elusive. Here, I discuss how a recent report on the sliding elevator mechanism, seen under the context of genetic analysis of a prototype fungal transporter, sheds light on how specificity might be genetically modified. I propose that flexible specificity alterations might occur by 'loosening' of the sliding mechanism from tight coupling to substrate binding.
科研通智能强力驱动
Strongly Powered by AbleSci AI