医学
中性粒细胞减少症
内科学
肺炎
人口
重症监护医学
多发性骨髓瘤
随机对照试验
外科
化疗
环境卫生
作者
Nicole Balmaceda,Muhammad Aziz,Viveksandeep Thoguluva Chandrasekar,Brian McClune,Suman Kambhampati,Leyla Shune,Al Ola Abdallah,Faiz Anwer,Aneela Majeed,Muzaffar H. Qazilbash,Siddhartha Ganguly,Joseph P. McGuirk,Ghulam Rehman Mohyuddin
出处
期刊:BMC Cancer
[Springer Nature]
日期:2021-06-26
卷期号:21 (1)
被引量:25
标识
DOI:10.1186/s12885-021-08451-x
摘要
Patients with multiple myeloma (MM) remain at an increased risk of infection due to the disease process, as well as the ensuing treatments.We performed a systematic review to evaluate the monthly risk of grade III/IV infection, pneumonia, and neutropenia in patients with myeloma enrolled in randomized clinical trials (RCTs).The risk of grade III or higher infection, pneumonia, and neutropenia persists among all phases of treatment. There was no statistical difference in grade III or higher infection, pneumonia, and neutropenia between frontline and relapsed/refractory setting. In the maintenance setting, the complications of infection, pneumonia, and neutropenia were low, but not negligible. Three-drug regimens were no more likely than two-drug regimens to have an increased risk of Grade III or higher infection.This is the first study to quantify the monthly risk of grade III or higher infection, pneumonia, and neutropenia across different treatment regimens in the frontline, maintenance, and relapsed/refractory settings. The results of our systematic review demonstrate a significant risk for severe infection, pneumonia, and neutropenia in patients with MM. Further studies are needed to determine the value of antibiotic prophylaxis in a broader myeloma patient population, as well as other approaches that will further mitigate the morbidity and mortality related to infection in this vulnerable patient population.
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