维加巴丁
化学
衍生化
分析物
色谱法
选择性
高效液相色谱法
有机化学
抗惊厥药
癫痫
生物
催化作用
神经科学
作者
Esmail Mohammadian,Elaheh Rahimpour,Alireza Foroumadi,Mahmood Alizadeh Sani,Zaman Hasanvand,Abolghasem Jouyban
标识
DOI:10.1080/10408347.2021.1916733
摘要
γ-Aminobutyric acid (GABA) plays an important role in regulating neuronal excitability. Four structurally related drugs to GABA including pregabalin (PGB), gabapentin (GBP), vigabatrin (VGB), and baclofen are used for the treatment of central nervous system disorders. These drugs are small aliphatic molecules having neither fluorescent nor strong absorbance in the ultraviolet/visible region; therefore, direct determination of these analytes by optical methods is difficult. Additionally, their high boiling point makes gas chromatography impossible. Accordingly, the amine or acid moiety in these drugs is derivatized in order to improve their selectivity and sensitivity during determination in the biological samples. This review focuses on derivatization based methods and their different reactions for determination of PGB, GBP, VGB, and baclofen in the biological samples and pharmaceutical preparations reported between 1980 and 2020. High-performance liquid chromatography methods coupled with different detectors are a commonly used methods for determination of GABA analogs after derivatization. These methods cover 38.89% of all developed methods for determination of GABA analogs.
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