免疫原性
氨肽酶
髓母细胞瘤
内质网
主要组织相容性复合体
MHC I级
剧目
癌症研究
计算生物学
生物
抗原
细胞生物学
免疫学
遗传学
氨基酸
亮氨酸
声学
物理
作者
Francesca Bufalieri,Doriana Fruci,Lucia Di Marcotullio
标识
DOI:10.1016/j.trecan.2021.09.005
摘要
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme that shapes the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules, thereby affecting tumor immunogenicity. ERAP1 is altered in many tumors, including medulloblastoma (MB). We review the role of ERAP1 in MB development and the possibility of targeting this enzyme for MB treatment.
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