环加成
化学
基质(水族馆)
催化作用
芳基
反应条件
功能群
范围(计算机科学)
组合化学
有机化学
药物化学
计算机科学
海洋学
烷基
聚合物
程序设计语言
地质学
作者
Xiaozhou Xie,Jiangtao Sun
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-11-01
卷期号:23 (22): 8921-8925
被引量:21
标识
DOI:10.1021/acs.orglett.1c03413
摘要
A catalyst-free [4+3]-cycloaddition reaction of N-aryl sulfilimines with cyclobutenones is described, which provides a straightforward protocol for synthesizing 1,5-dihydro-2H-benzo[b]azepin-2-ones under mild reaction conditions. This reaction features a broad substrate scope and good functional group tolerance and does not require catalysts or additives. Moreover, using N-pyridinyl sulfilimine as the substrate, a series of pyridoazepinones have also been prepared.
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