自愈水凝胶
生物相容性
壳聚糖
化学
海藻酸钠
生物材料
化学工程
组织工程
盐(化学)
铵
钠
高分子化学
生物医学工程
有机化学
医学
工程类
作者
Zhijie Geng,Yuxing Ji,Shan Yu,Qunfeng Liu,Zongbao Zhou,Cuiping Guo,Daohuan Lu,Dating Pei
标识
DOI:10.1016/j.carres.2021.108389
摘要
The development of cheap and easily available injectable hydrogel is an urgent problem in the field of biomedical engineering. Herein, we used chitosan quaternary ammonium salt and sodium alginate to prepare a dual crosslinking hydrogel. The hydrogel formed in-situ crosslinking and can be injected continuously. Interestingly, the formed hydrogel possessed a homogeneous 3D network structure and exhibited reasonable mechanical properties. Moreover, the hydrogels had excellent injectability, and the compression strength of the hydrogel (Gel-0.5) was up to 27.65 kPa. Additionally, the hydrogel showed good biocompatibility that evaluated by cytotoxicity. Notably, the hydrogel was nontoxic toward NIH-3T3 cells. In summary, the hydrogel we produced can be used as an ideal biomaterial for further applications in the field of biomedical engineering.
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