Solubility study of naproxen in the binary mixture of ethanol and ethylene glycol at different temperatures

Solubility and thermodynamic properties of naproxen in the binary mixtures of ethanol and ethylene glycol were determined by shake-flask method followed by a spectrophotometric method in the temperature range of 293.2–33.2.2 K. The acquired solubility values of naproxen are correlated by using some linear and non-linear solubility models such as the van't Hoff, the MRS, the Jouyban-Acree, the Jouyban-Acree-van't Hoff, the modified Wilson and the λh models. The accuracy of each used model is tested by the mean relative deviation of the back-calculated data. In addition, density values of saturated mixtures are also determined and represented by the Jouyban-Acree model at defined temperatures. Moreover, the apparent thermodynamic properties of naproxen are calculated based on van't Hoff and Gibbs equations.