Bakuchiol Contributes to the Hepatotoxicity ofPsoralea corylifoliain Rats

Phytotherapy ResearchVolume 31, Issue 8 p. 1265-1272 Research Article Bakuchiol Contributes to the Hepatotoxicity of Psoralea corylifolia in Rats Zhi-Jian Li, Zhi-Jian Li orcid.org/0000-0001-9358-9683 Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009 China Department of Toxicology Laboratory Xinjiang Institute of Traditional Uyghur Medicine, Xinjiang Laboratory of Uyghur Medical Prescription, Urumqi, Xinjiang, 830049 ChinaSearch for more papers by this authorAbudumijiti Abulizi, Abudumijiti Abulizi Basic Medical College, Xinjiang Medical University, Xinjiang Uyghur Autonomous Region, Urumqi, 830054 ChinaSearch for more papers by this authorGuo-Lin Zhao, Guo-Lin Zhao Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009 ChinaSearch for more papers by this authorTao Wang, Tao Wang Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009 ChinaSearch for more papers by this authorFan Zhou, Fan Zhou Xinjiang Huashidan Pharmaceutical Research Co., Ltd, Urumqi, Xinjiang, 830011 ChinaSearch for more papers by this authorZhen-Zhou Jiang, Zhen-Zhou Jiang Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009 ChinaSearch for more papers by this authorSilafu Aibai, Corresponding Author Silafu Aibai lyzhangchina@hotmail.com Department of Toxicology Laboratory Xinjiang Institute of Traditional Uyghur Medicine, Xinjiang Laboratory of Uyghur Medical Prescription, Urumqi, Xinjiang, 830049 China Correspondence to: Lu-Yong Zhang, Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, China; Silafu Aibai, Department of Pharmacology and Toxicology Laboratory Xinjiang Institute of Traditional Uyghur Medicine, Xinjiang Laboratory of Uyghur Medical Prescription, Urumqi, Xinjiang 830049, China. E-mail: lyzhangchina@hotmail.com (Lu-Yong Zhang); aibai1960@sina.com (Silafu Aibai)Search for more papers by this authorLu-Yong Zhang, Corresponding Author Lu-Yong Zhang aibai1960@sina.com Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009 China Correspondence to: Lu-Yong Zhang, Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, China; Silafu Aibai, Department of Pharmacology and Toxicology Laboratory Xinjiang Institute of Traditional Uyghur Medicine, Xinjiang Laboratory of Uyghur Medical Prescription, Urumqi, Xinjiang 830049, China. E-mail: lyzhangchina@hotmail.com (Lu-Yong Zhang); aibai1960@sina.com (Silafu Aibai)Search for more papers by this author Zhi-Jian Li, Zhi-Jian Li orcid.org/0000-0001-9358-9683 Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009 China Department of Toxicology Laboratory Xinjiang Institute of Traditional Uyghur Medicine, Xinjiang Laboratory of Uyghur Medical Prescription, Urumqi, Xinjiang, 830049 ChinaSearch for more papers by this authorAbudumijiti Abulizi, Abudumijiti Abulizi Basic Medical College, Xinjiang Medical University, Xinjiang Uyghur Autonomous Region, Urumqi, 830054 ChinaSearch for more papers by this authorGuo-Lin Zhao, Guo-Lin Zhao Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009 ChinaSearch for more papers by this authorTao Wang, Tao Wang Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009 ChinaSearch for more papers by this authorFan Zhou, Fan Zhou Xinjiang Huashidan Pharmaceutical Research Co., Ltd, Urumqi, Xinjiang, 830011 ChinaSearch for more papers by this authorZhen-Zhou Jiang, Zhen-Zhou Jiang Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009 ChinaSearch for more papers by this authorSilafu Aibai, Corresponding Author Silafu Aibai lyzhangchina@hotmail.com Department of Toxicology Laboratory Xinjiang Institute of Traditional Uyghur Medicine, Xinjiang Laboratory of Uyghur Medical Prescription, Urumqi, Xinjiang, 830049 China Correspondence to: Lu-Yong Zhang, Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, China; Silafu Aibai, Department of Pharmacology and Toxicology Laboratory Xinjiang Institute of Traditional Uyghur Medicine, Xinjiang Laboratory of Uyghur Medical Prescription, Urumqi, Xinjiang 830049, China. E-mail: lyzhangchina@hotmail.com (Lu-Yong Zhang); aibai1960@sina.com (Silafu Aibai)Search for more papers by this authorLu-Yong Zhang, Corresponding Author Lu-Yong Zhang aibai1960@sina.com Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu, 210009 China Correspondence to: Lu-Yong Zhang, Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, China; Silafu Aibai, Department of Pharmacology and Toxicology Laboratory Xinjiang Institute of Traditional Uyghur Medicine, Xinjiang Laboratory of Uyghur Medical Prescription, Urumqi, Xinjiang 830049, China. E-mail: lyzhangchina@hotmail.com (Lu-Yong Zhang); aibai1960@sina.com (Silafu Aibai)Search for more papers by this author First published: 22 June 2017 https://doi.org/10.1002/ptr.5851Citations: 28Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Psoralea corylifolia L. (Fructus Psoraleae) is widely used in Asia, but there are concerns about hepatotoxicity caused by constituents such as psoralens and bakukiol. Bakuchiol (BAK) has antiinflammatory, antipyretic, antibacterial antiviral, anticancer, and estrogenic activity but appears to be hepatotoxic in in vitro tests. This study investigated the hepatotoxicity in vivo in rats. Using intragastrically administered bakuchiol at doses of 52.5 and 262.5 mg/kg for 6 weeks. Bodyweight, relative liver weight, biochemical indicators, histopathology, mRNA expression of CYP7A1, HMG-CoA reductase, BSEP, PPARα, SREBP-2, and MRP3 were measured. Many abnormalities were observed in the bakuchiol-treated groups including suppression of weight gain and food intake, change of some parameters in serum biochemistry, and increased weight of liver. The mRNA expression of CYP7A1, HMG-CoA reductase, PPARα, and SREBP-2 decreased in bakuchiol-treated group, the expression of BSEP increased in bakuchiol-treated low dosage, and the expression of BSEP decreased in bakuchiol-treated high dosage. In conclusion, we provide evidence for the first time that bakuchiol can induce cholestatic hepatotoxicity, suggesting potential hepatotoxicity. The mechanism may be related to effects on liver lipid metabolism, but further investigation is necessary. Copyright © 2017 John Wiley & Sons, Ltd. Citing Literature Volume31, Issue8August 2017Pages 1265-1272 RelatedInformation