滚动圆复制
模板
纳米结构
DNA
环介导等温扩增
纳米技术
DNA纳米技术
DNA测序
计算机科学
化学
计算生物学
材料科学
生物
DNA复制
生物化学
作者
Yuwei Xu,Zhaoyue Lv,Chi Yao,Dayong Yang
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:10 (12): 3054-3061
被引量:23
摘要
DNA-based materials exhibit great potential in biomedical applications due to their excellent sequence programmability and unique functional designability. Rolling circle amplification (RCA) is an efficient isothermal enzymatic amplification strategy to produce ultralong single-stranded DNA with customized functional moieties. The rational design of RCA templates and the introduction of other functional components enable RCA-based DNA materials with structural dynamic responsiveness and diverse biological functions, facilitating the development of DNA-based materials in biomedical applications. In this review, the principle and synthetic methods of RCA and the recent progress of RCA-based DNA nanostructures for therapeutics and bioimaging are summarized and discussed. The future challenges and opportunities for RCA-based DNA nanostructures are discussed at the end of the study. We envision that the development of RCA-based DNA nanostructures will provide more possibilities for precision medicine.
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