Coronary computed tomography angiography evaluation of plaque morphology and its relationship to HDL and total cholesterol to HDL ratio

医学 动脉粥样硬化 冠状动脉疾病 内科学 胆固醇 易损斑块 心脏病学 计算机断层血管造影 高密度脂蛋白 人口 血管造影 环境卫生
作者
Venkat Sanjay Manubolu,Dhiran Verghese,Suvasini Lakshmanan,Luay Alalawi,April Kinninger,Jairo Aldana-Bitar,Francesca Calicchio,Khadije Ahmad,Ahmed Ghanem,Denise Alison Javier,Czarina Mangaoang,Ferdinand Flores,Christopher Dailing,Sion K. Roy,Matthew J. Budoff
出处
期刊:Journal of Clinical Lipidology [Elsevier BV]
卷期号:16 (5): 715-724 被引量:5
标识
DOI:10.1016/j.jacl.2022.06.003
摘要

Background While population studies have demonstrated that high density lipoprotein cholesterol (HDL-C) and the ratio of total cholesterol to HDL (TC/HDL) improve cardiovascular risk prediction, the mechanism by which these parameters protect the cardiovascular system remains uncertain. Objective To investigate the relationship between the HDL-C level and the total cholesterol to HDL (TC/HDL) ratio with the morphology of coronary artery plaque as determined by coronary computed tomography angiography (CCTA). Methods This is a cross-sectional study involving 190 subjects with stable coronary artery disease. Semi-automated plaque analysis software was utilized to quantify plaque and plaque volumes are presented as total atheroma volume normalized (TAVnorm). Multivariate regression models were used to evaluate the association of HDL-C and TC/HDL ratio with coronary plaque volumes. Results Of the 190 subjects the average (SD) age was 58.9 (9.8) years, with 63% being male. After adjustment for cardiovascular risk factors, HDL- C (>40 mg/dl) is inversely associated with fibrous (p = 0.003), fibrous fatty (p = 0.007), low attenuation plaque (LAP) (p = 0.007), total non-calcified plaque (TNCP) (p = 0.002) and total plaque (TP)(p = 0.004) volume. Furthermore, the TC/HDL ratio (> 4.0) is associated with fibrous (p = 0.047) and total non-calcified plaque (p = 0.039), but not with fibrofatty, LAP, dense calcified plaque, or TP volume. Conclusion There is a strong association between low HDL-C levels and increasing TC/HDL ratio with certain types of coronary plaque characteristics, independent of traditional risk factors. The findings of this study suggest mechanistic evidence supporting the protective role of HDL-C and the TC/HDL ratio's clinical relevance in coronary artery disease management.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
杨三多发布了新的文献求助10
刚刚
情怀应助蓝心语采纳,获得10
1秒前
2秒前
2秒前
3秒前
Ultraman45发布了新的文献求助10
3秒前
咖啡续命发布了新的文献求助10
4秒前
量子星尘发布了新的文献求助10
5秒前
英姑应助有只长脖鹿采纳,获得10
5秒前
xubee发布了新的文献求助10
7秒前
7秒前
李健应助hh采纳,获得10
9秒前
符小俊完成签到,获得积分10
11秒前
Nicole发布了新的文献求助10
11秒前
12秒前
Zxc发布了新的文献求助10
12秒前
12秒前
lala完成签到,获得积分10
13秒前
充电宝应助科研通管家采纳,获得10
14秒前
SciGPT应助科研通管家采纳,获得10
14秒前
科研通AI5应助科研通管家采纳,获得30
14秒前
思源应助科研通管家采纳,获得10
15秒前
15秒前
15秒前
深情安青应助科研通管家采纳,获得10
15秒前
顾矜应助科研通管家采纳,获得10
15秒前
共享精神应助科研通管家采纳,获得10
15秒前
JamesPei应助科研通管家采纳,获得10
15秒前
15秒前
15秒前
SciGPT应助科研通管家采纳,获得10
15秒前
15秒前
15秒前
赘婿应助科研通管家采纳,获得10
15秒前
贺九九完成签到,获得积分20
16秒前
17秒前
notsoeasy发布了新的文献求助10
19秒前
21秒前
LouisYRJ应助Zxc采纳,获得40
23秒前
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976210
求助须知:如何正确求助?哪些是违规求助? 3520366
关于积分的说明 11203088
捐赠科研通 3256965
什么是DOI,文献DOI怎么找? 1798570
邀请新用户注册赠送积分活动 877738
科研通“疑难数据库(出版商)”最低求助积分说明 806516