Use of Dynamic Chest Radiography to Assess Treatment of Pulmonary Exacerbations in Cystic Fibrosis

医学 肺活量测定 四分位间距 肺活量 肺容积 肺功能测试 射线照相术 秩相关 内科学 核医学 放射科 哮喘 扩散能力 肺功能 机器学习 计算机科学
作者
Thomas Simon FitzMaurice,Caroline McCann,D. Nazareth,Paul McNamara,Martin Walshaw
出处
期刊:Radiology [Radiological Society of North America]
卷期号:303 (3): 675-681 被引量:16
标识
DOI:10.1148/radiol.212641
摘要

Background Although spirometry is an important marker in the management of pulmonary exacerbations in cystic fibrosis (CF), it is a forced maneuver and can generate aerosol. Therefore, it may be difficult to perform in some individuals. Dynamic chest radiography (DCR) provides real-time information regarding pulmonary dynamics alongside fluoroscopic-style thoracic imaging. Purpose To assess the effect of pulmonary exacerbation treatment by using both spirometry and DCR and assess the clinical utility of DCR in participants with CF experiencing pulmonary exacerbations. Materials and Methods In this prospective, observational, single-center pilot study, spirometry and DCR were performed before and after treatment of pulmonary exacerbations in participants with CF between December 2019 and August 2020. Spirometry measured forced expiratory volume in 1 second (FEV1) and forced vital capacity. DCR helped to measure projected lung area (PLA), hemidiaphragm midpoint position, and speed during tidal and deep breathing. Data were analyzed by using the paired t test or Wilcoxon signed-rank test. Correlation was assessed by using the Spearman rank correlation coefficient. Results Twenty participants with CF (mean age, 25 years ± 7 [standard deviation]; 14 women) were evaluated. Spirometry showed that percentage predicted FEV1 improved from a median of 44% (interquartile range [IQR], 17%) before treatment to 55% (IQR, 16%) after treatment (P = .004). DCR showed improvement in median deep breathing excursion for left and right hemidiaphragms (from 18 [IQR, 11] to 25 [IQR, 16] mm [P = .03] and from 13 [IQR, 6] to 19 [IQR, 14] mm [P = .03], respectively) and in median expiratory speed following deep breathing for left and right hemidiaphragms (from 7 [IQR, 2] to 11 [IQR, 5] mm/sec [P = .004] and 6 [IQR, 3] to 9 [IQR, 6] mm/sec [P = .004], respectively). PLA rate of change during full expiration and change in PLA during tidal breathing improved (from a mean of 42 cm2/sec ± 16 to 56 cm2/sec ± 24 [P = .03] and from a mean of 29 cm2 ± 14 to 35 cm2 ± 10 [P = .03], respectively). Conclusion Dynamic chest radiography demonstrated improvement in diaphragm speed and range of chest wall movement during respiration aftere treatment for pulmonary exacerbations in cystic fibrosis and showed potential as a tool to investigate the effect of pulmonary exacerbations on lung mechanics. Clinical trials registration no. NCT01234567 Published under a CC BY 4.0 license. Online supplemental material is available for this article.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
平淡尔琴完成签到,获得积分10
刚刚
我很好完成签到 ,获得积分10
2秒前
小白鞋完成签到 ,获得积分10
5秒前
帅气的藏鸟完成签到,获得积分10
6秒前
摘星012完成签到 ,获得积分10
6秒前
demian完成签到,获得积分20
7秒前
woshiwuziq完成签到 ,获得积分10
9秒前
drtianyunhong完成签到,获得积分10
9秒前
八八九九九1完成签到,获得积分10
13秒前
优雅的千雁完成签到,获得积分10
14秒前
没用的三轮完成签到,获得积分10
15秒前
17秒前
你我的共同完成签到 ,获得积分10
19秒前
mayberichard完成签到,获得积分10
21秒前
风信子deon01完成签到,获得积分10
24秒前
Pt-SACs发布了新的文献求助10
24秒前
香山叶正红完成签到 ,获得积分10
25秒前
wsg完成签到,获得积分10
25秒前
serendipity完成签到 ,获得积分10
27秒前
爆米花应助Yong-AI-BUPT采纳,获得10
28秒前
Pt-SACs完成签到,获得积分10
33秒前
刚子完成签到 ,获得积分10
34秒前
nicky完成签到 ,获得积分10
34秒前
果冻橙完成签到,获得积分10
36秒前
36秒前
田様应助科研通管家采纳,获得10
36秒前
Xiaoxiao应助科研通管家采纳,获得10
36秒前
思源应助科研通管家采纳,获得10
36秒前
37秒前
39秒前
火星人完成签到 ,获得积分10
40秒前
四叶草完成签到 ,获得积分10
41秒前
干净的沛蓝完成签到,获得积分10
41秒前
Yong-AI-BUPT发布了新的文献求助10
43秒前
琥1发布了新的文献求助10
43秒前
livra1058完成签到,获得积分10
43秒前
朴素的紫安完成签到 ,获得积分10
43秒前
火星上小土豆完成签到 ,获得积分10
44秒前
Silole完成签到,获得积分10
45秒前
Yong-AI-BUPT完成签到,获得积分10
52秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968578
求助须知:如何正确求助?哪些是违规求助? 3513391
关于积分的说明 11167428
捐赠科研通 3248822
什么是DOI,文献DOI怎么找? 1794499
邀请新用户注册赠送积分活动 875116
科研通“疑难数据库(出版商)”最低求助积分说明 804664