作者
Daisuke Kotani,Yoshiaki Nakamura,Takao Fujisawa,Hideaki Bando,Naoya Sakamoto,Amber L Johns,Keunchil Park,Raffaella Casolino,Takayuki Yoshino,Andrew V Biankin,Andrew V Biankin,Lincoln D Stein,Keunchil Park,Rita T Lawlor,Amber L Johns,Jan O Korbel,Nik Zeps,Mark A Rubin,Marco A Marra,Olivier Elemento,Steven Gallinger,David Tuveson,Lorenz Trumper,Raphael Koch,Aldo Scarpa,Paul Brennan,Christian Pilarsky,Sergey Nikolaev,Sun-Soo Yoon,Eun Sook Lee,Tatsuhiro Shibata,Xiaojian Wu,Jianmin Wu,Qimin Zhan,Wai Poon,Takayuki Yoshino,Khawla S. Al-Kuraya,Rosalind Eeles,Rebecca Fitzgerald,Carlos Caldas,Jean Abraham,David K Chang
摘要
Colorectal cancer is characterised by high molecular heterogeneity and genomic alterations in common cancer drivers, including RAS, BRAF, and mismatch repair genes, which are routinely assessed to inform precision treatments. However, constant clonal evolution is common and leads to therapeutic resistance. Longitudinal molecular analysis of integrated tissue and liquid biopsies is essential to monitor the molecular evolution of colorectal cancer during the continuum of care and inform sequential adaptive therapies based on real-time genomic changes.
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