Curcumin protects against diabetic cardiomyopathy by promoting autophagy and alleviating apoptosis

自噬 姜黄素 糖尿病性心肌病 安普克 细胞凋亡 体内 糖尿病 药理学 体外 链脲佐菌素 医学 化学 细胞生物学 心肌病 内科学 内分泌学 心力衰竭 生物 磷酸化 蛋白激酶A 生物化学 生物技术
作者
Qing Yao,Zhiqiang Ke,Shuang Guo,Xiaosong Yang,Fei-Xue Zhang,Xiufen Liu,Xiao Chen,Hongguang Chen,Huan-ya Ke,Chao Liu
出处
期刊:Journal of Molecular and Cellular Cardiology [Elsevier BV]
卷期号:124: 26-34 被引量:121
标识
DOI:10.1016/j.yjmcc.2018.10.004
摘要

The effects of curcumin on regulating cardiac apoptosis and autophagy were analyzed in diabetic models both in vivo and in vitro. In vivo, experimental diabetes was induced in mice by low-dose STZ injection combined with a high-fat diet. In vitro, cultured H9c2 cardiomyoblasts were exposed to high d-glucose concentrations combined with palmitate. Our results showed that apoptosis was increased and autophagy was suppressed in the hearts of diabetic mice, which was ameliorated by curcumin treatment, ultimately improving cardiac function. Moreover, the inhibition of autophagy exacerbated apoptotic death in cardiac cells under diabetic condition. Curcumin activated AMPK and JNK1, which phosphorylated Bcl-2 and Bim and subsequently disrupted their interactions with Beclin1, thereby promoting autophagy and alleviating apoptosis respectively. In addition, AMPK-mediated inhibition of mTORC1 pathway likely played a role in regulating autophagy by curcumin under diabetic condition. Our study suggests that curcumin protects against diabetic cardiomyopathy by modulating the crosstalk between autophagic and apoptotic machinery. Modulation of autophagy may be an effective strategy for the treatment of cardiovascular diseases associated with diabetes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
善学以致用应助Kelsey采纳,获得10
1秒前
桐桐应助迟迟采纳,获得10
3秒前
陈博士完成签到,获得积分10
4秒前
脑洞疼应助最牛的kangkang采纳,获得10
5秒前
lbb黎完成签到,获得积分10
5秒前
123发布了新的文献求助10
5秒前
6秒前
hx完成签到 ,获得积分10
6秒前
牧紊完成签到 ,获得积分10
7秒前
7秒前
陈博士发布了新的文献求助10
8秒前
9秒前
12秒前
123完成签到,获得积分10
13秒前
吃饭饭完成签到,获得积分20
14秒前
14秒前
123完成签到,获得积分10
14秒前
wanci应助hhh采纳,获得10
14秒前
Hello应助欣慰的乌冬面采纳,获得10
15秒前
15秒前
16秒前
16秒前
柯一一应助西米采纳,获得10
16秒前
17秒前
18秒前
CipherSage应助笔墨留香采纳,获得10
18秒前
爱u发布了新的文献求助10
19秒前
迟迟发布了新的文献求助10
20秒前
金山完成签到,获得积分10
22秒前
细雨发布了新的文献求助10
22秒前
wtt发布了新的文献求助10
22秒前
23秒前
24秒前
24秒前
形容完成签到,获得积分10
25秒前
26秒前
思源应助jackdawjo采纳,获得10
27秒前
27秒前
123发布了新的文献求助10
28秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975658
求助须知:如何正确求助?哪些是违规求助? 3519986
关于积分的说明 11200481
捐赠科研通 3256410
什么是DOI,文献DOI怎么找? 1798247
邀请新用户注册赠送积分活动 877490
科研通“疑难数据库(出版商)”最低求助积分说明 806376