发病机制
基因
动脉瘤
蛛网膜下腔出血
医学
遗传学
生物信息学
病理
内科学
生物
外科
作者
Quan Cheng,Zhenyan Li,Ruizhe Wang,Hongfu Zhang,Hui Cao,Fenghua Chen,Huangbao Li,Zhiwei Xia,Songshan Feng,Hao Zhang,Yuhua Rui,Fan Fan
标识
DOI:10.1016/j.wneu.2019.06.110
摘要
Intracranial aneurysm (IA) represents a cerebrovascular disorder that featured by dilation or bulging of the weakened blood vessel wall. When it ruptures, an IA leads to subarachnoid hemorrhage with high disability and mortality rates. Despite the numerous studies focusing on IA ruptures, little research on IA pathogenesis has been reported. In this study, we aimed to reveal key genes related to IA formation. Four datasets from Gene Expression Omnibus data were downloaded, normalized, and separated into the IA group and the normal vessel control group for analyses. We screened for differentially expressed genes (DEGs) between groups and conducted functional enrichment, pathway enrichment, and gene set enrichment analysis analyses among significant DEGs. according to our analyses, significant DEGs majorly associate with smooth muscle system and the complement system. Among all DEGs, 5 down-regulated genes (MYH11, CNN1, MYOCD, ACTA1, and LMOD1) and 3 up-regulated genes (C1QB, C3AR1, and VSIG4) are most relevant in IA formation. Key DEGs identified in this study are related to IA pathogenesis. Among identified DEGs, LMOD1 is the most significant and merits more attention.
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