Immunoliposomes in Acute Myeloid Leukaemia Therapy: An Overview of Possible Targets and Obstacles

髓性白血病 医学 免疫学 髓样 癌症研究
作者
Aditi Singh,Nikolai Norevik Myklebust,Sarah Marie Vie Furevik,Ragnhild Haugse,Lars Herfindal
出处
期刊:Current Medicinal Chemistry [Bentham Science Publishers]
卷期号:26 (28): 5278-5292 被引量:9
标识
DOI:10.2174/0929867326666190517114450
摘要

Acute Myeloid Leukaemia (AML) is the neoplastic transformation of Hematopoietic Stem Cells (HSC) and relapsed disease is a major challenge in the treatment. Despite technological advances in the field of medicine and our heightened knowledge regarding the pathogenesis of AML, the initial therapy of "7+3" Cytarabine and Daunorubicin has remained mainly unchanged since 1973. AML is a disease of the elderly, and increased morbidity in this patient group does not allow the full use of the treatment and drug-resistant relapse is common. Nanocarriers are drug-delivery systems that can be used to transport drugs to the bone marrow and target Leukemic Stem Cells (LSC), conferring less side-effects compared to the free-drug alternative. Nanocarriers also can be used to favour the transport of drugs that otherwise would not have been used clinically due to toxicity and poor efficacy. Liposomes are a type of nanocarrier that can be used as a dedicated drug delivery system, which can also have active ligands on the surface in order to interact with antigens on the target cells or tissues. In addition to using small molecules, it is possible to attach antibodies to the liposome surface, generating so-called immunoliposomes. By using immunoliposomes as a drug-delivery system, it is possible to minimize the toxic side effects caused by the chemotherapeutic drug on healthy organs, and at the same time direct the drugs towards the remaining AML blasts and stem cells. This article aims to explore the possibilities of using immunoliposomes as a drug carrier in AML therapy. Emphasis will be on possible target molecules on the AML cells, leukaemic stem cells, as well as bone marrow constituents relevant to AML therapy. Further, some conditions and precautions that must be met for immunoliposomes to be used in AML therapy will be discussed.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
P2JY完成签到,获得积分10
1秒前
leiiiiiiii完成签到,获得积分10
1秒前
Bake完成签到 ,获得积分10
3秒前
4秒前
yuan完成签到,获得积分10
4秒前
论文多多完成签到,获得积分10
5秒前
5秒前
Acid完成签到 ,获得积分10
5秒前
1111111111111发布了新的文献求助10
6秒前
linlinyilulvdeng完成签到,获得积分10
6秒前
斯文败类应助历史雨采纳,获得10
7秒前
FashionBoy应助吃个大笼包采纳,获得10
9秒前
海阔天空发布了新的文献求助10
10秒前
薛建伟发布了新的文献求助10
11秒前
高高代珊发布了新的文献求助10
12秒前
害羞的墨镜完成签到,获得积分10
12秒前
lalala发布了新的文献求助10
12秒前
13秒前
guojingjing完成签到,获得积分10
13秒前
打打应助科多兽骑士采纳,获得10
14秒前
angela完成签到,获得积分10
14秒前
14秒前
潇洒的茗茗完成签到 ,获得积分10
16秒前
脂肪小米粥完成签到,获得积分10
17秒前
小幸运完成签到,获得积分10
20秒前
爱吃冻梨完成签到,获得积分10
20秒前
xiang发布了新的文献求助10
20秒前
陈冲冲完成签到,获得积分10
21秒前
changfox完成签到,获得积分10
21秒前
22秒前
22秒前
孙晓燕完成签到 ,获得积分10
22秒前
22秒前
望着拥有完成签到,获得积分10
22秒前
23秒前
xcx发布了新的文献求助10
25秒前
Jeri完成签到 ,获得积分10
26秒前
Harlotte完成签到 ,获得积分10
27秒前
27秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038619
求助须知:如何正确求助?哪些是违规求助? 3576294
关于积分的说明 11375058
捐赠科研通 3306084
什么是DOI,文献DOI怎么找? 1819374
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815066