Bidirectional communication between cumulus cells and oocytes

The bidirectional communication mechanism between cumulus cells (CCs) and oocytes are currently being investigated. Small molecule transport and signal transduction between CCs and oocytes regulate oocyte development and ovulation through gap junction. Oocytes determine the proliferation and differentiation of CCs by secretion of oocyte-secreted factors (OSFs), thereby regulating the development of oocytes and preventing follicular luteinization. In addition, OSFs are also closely related to the glycolytic pathway. In recent years, by studying the role of non-coding RNAs (ncRNAs) in female germ cells, new ideas have been provided to further improve the bidirectional communication mechanism. Because the bidirectional communication mechanism between CCs and oocytes is very complicated, it is still a huge challenge to clarify the mechanism of action. This article aims to review bidirectional communication mechanism between CCs and oocytes. Key words: Cumulus cells; Oocytes; Bidirectional communication; Non-coding RNAs