已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Down-regulation of Gremlin1 inhibits inflammatory response and vascular permeability in chronic idiopathic urticaria through suppression of TGF-β signaling pathway

组胺 炎症 生物 信号转导 转化生长因子 微阵列分析技术 微阵列 免疫学 激活剂(遗传学) 血管通透性 细胞生物学 癌症研究 基因表达 受体 药理学 内分泌学 基因 生物化学
作者
Shengming Qu,Zhe Liu,Bing Wang
出处
期刊:Gene [Elsevier BV]
卷期号:756: 144916-144916 被引量:11
标识
DOI:10.1016/j.gene.2020.144916
摘要

• The mechanism of silencing GREM1 is firstly explored in CIU. • High tryptase, β-hexosaminase, and histamine in CIU serum. • Silencing GREM1 inhibits TGF-β and inflammatory response in CIU. • Inhibited TGF-β suppresses CIU development. • GREM1 and TGF-β are the new treatment targets for CIU. Chronic idiopathic urticaria (CIU) is an unfavorable skin condition which could be maintained for six weeks or longer time. Gremlin1 (GREM1) was recently applied in treatments of many diseases. However, the possible regulatory mechanism of GREM1 in CIU remained unclear. This study aimed to explore the regulatory effects of GREM1 on the inflammatory response and vascular permeability mediated by mast cells of CIU via TGF-β signaling pathway. Initially, microarray analysis was used to identify CIU-related differentially expressed genes and the potential mechanism of this gene. A mouse model of CIU was established. To explore the functional role of GREM1 in CIU, the modeled mice were then injected with GREM1-siRNA, SRI-011381 (the activator of TGF-β signaling pathway), or both, followed by serum test, and immunoglobulin detection. The levels of inflammatory factors and tryptase, β-hexosaminase, histamine in the serum were detected. Besides, vascular endothelial cell permeability and the target relation between GREM1 and TGF-β were also examined. Mice injected with SRI-011381 exhibited higher levels of tryptase, β-hexosaminase, histamine, inflammation-related factors and increased vascular endothelial cell permeability, while GREM1-silenced mice yet expressed opposite tendency. Silencing of GREM1 was demonstrated to inhibit the TGF-β signaling pathway. Taken together, our results demonstrated that down-regulation of GREM1 could potentially impede inflammatory response and vascular permeability by suppressing TGF-β signaling pathway. GREM1 may promote the development of prognosis management and therapeutic treatment in CIU.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
6秒前
7秒前
nicenice发布了新的文献求助10
12秒前
咕噜噜完成签到,获得积分10
16秒前
闫雪发布了新的文献求助10
17秒前
18秒前
22秒前
23秒前
Simpson完成签到 ,获得积分10
26秒前
www发布了新的文献求助10
27秒前
我是老大应助ceeray23采纳,获得20
30秒前
李爱国应助zzzkyt采纳,获得10
33秒前
lb001完成签到 ,获得积分10
35秒前
zzjjyy完成签到,获得积分10
36秒前
小刘发布了新的文献求助10
39秒前
41秒前
zzzkyt完成签到,获得积分10
41秒前
万能图书馆应助www采纳,获得10
44秒前
zzzkyt发布了新的文献求助10
45秒前
Hyh_orz应助onlyan采纳,获得20
46秒前
47秒前
48秒前
霜鸣完成签到,获得积分20
48秒前
霜鸣发布了新的文献求助10
54秒前
55秒前
lynn完成签到,获得积分10
56秒前
xiaoleihu完成签到 ,获得积分10
56秒前
singber完成签到,获得积分10
56秒前
龙猫爱看书完成签到,获得积分10
57秒前
ceeray23发布了新的文献求助20
1分钟前
梦醒了完成签到 ,获得积分10
1分钟前
111111完成签到,获得积分10
1分钟前
赘婿应助科研通管家采纳,获得10
1分钟前
xdlongchem完成签到,获得积分10
1分钟前
eee完成签到 ,获得积分10
1分钟前
cherlie完成签到,获得积分10
1分钟前
1分钟前
1分钟前
2213sss完成签到,获得积分10
1分钟前
aa完成签到,获得积分10
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532047
关于积分的说明 11256141
捐赠科研通 3270918
什么是DOI,文献DOI怎么找? 1805105
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216