Treatment of oropharyngeal candidiasis in immunocompetent infants: a randomized multicenter study of miconazole gel vs. nystatin suspension

咪康唑 制霉菌素 医学 随机对照试验 画眉 内科学 临床试验 胃肠病学 抗真菌 皮肤病科 宫颈癌 癌症 人乳头瘤病毒
作者
J E Hoppe
出处
期刊:Pediatric Infectious Disease Journal [Ovid Technologies (Wolters Kluwer)]
卷期号:16 (3): 288-293 被引量:48
标识
DOI:10.1097/00006454-199703000-00007
摘要

Background. Miconazole gel has previously been shown to be an effective treatment for oropharyngeal candidiasis (thrush) in immunocompetent infants. This study compares miconazole gel with the standard therapeutic agent, nystatin suspension, with regard to efficacy, optimal duration of therapy and safety. Design. Prospective multicenter, randomized, office-based open trial. Patients. Twenty-six pediatricians enrolled 227 immunocompetent infants with signs of oropharyngeal thrush. Subjects were randomly assigned to receive 25 mg of miconazole as oral gel four times daily or 100 000 IU of nystatin as suspension four times daily after meals. All subjects were evaluated for safety. Fifteen patients whose thrush was not confirmed by culture were excluded from further analysis. The remaining 212 subjects were entered into an intention-totreat analysis. Another 29 patients violated the study protocol; the remaining 183 subjects were evaluated for efficacy (per protocol analysis). Results. Clinical cure by Day 5 of treatment was demonstrated in 84.7% of the 98 subjects in the miconazole group and 21.2% of the 85 subjects in the nystatin group (P < 0.0001). By Day 8, the cumulative clinical cure rates were 96.9% (miconazole) and 37.6% (nystatin), respectively (P < 0.0001). By Day 12, 99.0% of subjects in the miconazole group and 54.1% of subjects in the nystatin group were clinically cured (P < 0.0001). Premature cessation of treatment at parents' request because of lack of clinical efficacy occurred in none of the infants treated with miconazole and in 6 infants treated with nystatin (P = 0.029). The oral yeast eradication rate on Day 5 was 54.1% with miconazole and 8.2% with nystatin (P < 0.0001). Clinical relapses of oropharyngeal thrush and side effects of the study drugs were observed with similar frequency in both study arms. Conclusions. Miconazole gel was significantly superior to nystatin suspension with regard to efficacy, rapidity of achieving cure and oropharyngeal yeast eradication. Relapses and side effects did not occur more frequently with miconazole than with nystatin. The results of this study indicate that miconazole gel is superior to nystatin suspension as the treatment for oropharyngeal candidiasis in immunocompetent infants.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
领导范儿应助不要酸橘子采纳,获得10
刚刚
刚刚
刚刚
Jasper应助迷你的心情采纳,获得10
2秒前
无言已对完成签到,获得积分10
2秒前
2秒前
4秒前
5秒前
斯文败类应助乐多子采纳,获得10
5秒前
5秒前
6秒前
6秒前
科目三应助xxxBlo采纳,获得10
6秒前
靓丽谷雪发布了新的文献求助30
6秒前
蜗牛完成签到 ,获得积分20
7秒前
9秒前
9秒前
10秒前
13秒前
小二郎应助无言已对采纳,获得10
13秒前
14秒前
16秒前
靓丽谷雪完成签到,获得积分10
16秒前
热心丹南完成签到,获得积分20
18秒前
青尘枫叶发布了新的文献求助10
19秒前
19秒前
无花果应助高高诗柳采纳,获得10
20秒前
planA完成签到,获得积分10
21秒前
21秒前
qisuo发布了新的文献求助10
21秒前
21秒前
鳗鱼鞋垫发布了新的文献求助10
22秒前
mm完成签到,获得积分10
22秒前
cllcx完成签到,获得积分10
23秒前
shuohan22发布了新的文献求助10
23秒前
fqx379应助Roxan采纳,获得10
24秒前
25秒前
25秒前
赘婿应助sqk采纳,获得50
25秒前
高分求助中
Handbook of Fuel Cells, 6 Volume Set 1666
求助这个网站里的问题集 1000
Floxuridine; Third Edition 1000
Tracking and Data Fusion: A Handbook of Algorithms 1000
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 800
消化器内視鏡関連の偶発症に関する第7回全国調査報告2019〜2021年までの3年間 500
One Man Talking: Selected Essays of Shao Xunmei, 1929–1939 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 内科学 物理 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 冶金 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 2863206
求助须知:如何正确求助?哪些是违规求助? 2469000
关于积分的说明 6695581
捐赠科研通 2159687
什么是DOI,文献DOI怎么找? 1147272
版权声明 585212
科研通“疑难数据库(出版商)”最低求助积分说明 563693