化学
肌酐
丙氨酸
二甘醇
果糖
色谱法
胺气处理
高效液相色谱法
氨基酸
有机化学
生物化学
乙二醇
作者
Spiros Grivas,Tomas Nyhammar,Kjell Olsson,Margaretha Jägerstad
标识
DOI:10.1016/0027-5107(85)90069-7
摘要
A mixture of creatinine, D-fructose and DL-alanine was heated in diethylene glycol containing 14% water for 2 h at ca. 128°C. The mutagens formed were extracted with 1-butanol, and purified by cation-exchange column chromatography, C18 reversed-phase Sep-Pak treatment and reversed-phase HPLC. According to its UV absorption, mass and 1H NMR spectra, one isolated fraction was tentatively assigned the chemical name, 3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine (4,8-DiMeIQx). This finding is in agreement with the suggestion that sugars, amino acids and creatinine present in meat may be the precursors of the mutagenic imidazoquinolin- and imidazoquinoxalin-2-amines (IQ compounds).
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