地址
整合素
生物
淋巴细胞归巢受体
高内皮静脉
细胞粘附分子
阿尔法(金融)
淋巴细胞
细胞生物学
分子生物学
受体
免疫学
细胞粘附
生物化学
细胞
医学
护理部
患者满意度
结构效度
作者
C Berlin,Ellen L. Berg,Michael Briskin,David P. Andrew,Peter J. Kilshaw,Bernhard Holzmann,Irving L. Weissman,Alf Hamann,Eugene C. Butcher
出处
期刊:Cell
[Elsevier]
日期:1993-07-01
卷期号:74 (1): 185-195
被引量:1398
标识
DOI:10.1016/0092-8674(93)90305-a
摘要
The mucosal vascular addressin, MAdCAM-1, is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer's patches (PP) and the intestinal lamina propria. We demonstrate that the lymphocyte integrin alpha 4 beta 7, also implicated in homing to PP, is a receptor for MAdCAM-1. Certain antibodies to alpha 4 and beta 7 integrin chains but not to the beta 2 integrin LFA-1 inhibit lymphocyte binding to purified MAdCAM-1 and to MAdCAM-1 transfectants. Lymph node lymphocytes, alpha 4 beta 7+ TK1 lymphoma cells, and a beta 7-transfected variant of an alpha 4+ B cell line, 38C13, bind constitutively to MAdCAM-1. Binding is enhanced by Mn(++)-induced integrin activation. The related integrin alpha 4 beta 1 supports efficient binding to VCAM-1 but not to MAdCAM-1, even after integrin activation, indicating that MAdCAM-1 is a preferential ligand for alpha 4 beta 7. Alpha 4 beta 7 can also bind VCAM-1, but this requires greater integrin activation than binding to MAdCAM-1. The findings imply a selective role for the interaction of alpha 4 beta 7 and MAdCAM-1 lymphocyte in homing to mucosal sites.
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