求新
被盖腹侧区
报酬依赖
新颖性
心理学
神经科学
伏隔核
好奇心
功能磁共振成像
黑质
奖励制度
感觉寻求
腹侧纹状体
认知心理学
人格
多巴胺能
五大性格特征
纹状体
多巴胺
社会心理学
作者
Ruth M. Krebs,Björn H. Schott,Emrah Düzel
标识
DOI:10.1016/j.biopsych.2008.08.019
摘要
The long-standing observation that the novelty-seeking personality trait is a predictor of drug use and other reinforcable risky behaviors raises the question as to how novelty and reward processing functionally interact in mesolimbic dopaminergic circuitry and how this interaction is modulated by the novelty-seeking personality trait.Functional magnetic resonance imaging (fMRI) hemodynamic responses to novelty and reward (monetary incentive) from the substantia nigra/ventral tegmental area (SN/VTA), the nucleus accumbens (NAcc), and the hippocampus of 29 subjects were correlated with novelty-seeking scores. These correlations were compared with those obtained for scores of reward-dependence. The fMRI data were taken from two experiments in which the interaction of novelty and reward was manipulated as a within-subject variable, and long-term memory for the critical stimuli was assessed after 24 hours.Novelty-seeking was positively correlated with SN/VTA activation elicited by novel cues that did not predict reward, whereas reward-dependence was related to activations elicited by novel cues that predicted reward. The positive correlation between SN/VTA responses to novelty and novelty-seeking scores was accompanied by a negative correlation with reward-related SN/VTA activation and memory enhancement.SN/VTA responses to novelty and reward are differentially affected by personality traits of novelty-seeking and reward-dependence. Importantly, novelty-seekers were more responsive to novel cues in the absence of reward and needed less reward to boost their memory for novel cues. These observations strongly suggest that for novelty-seekers, the motivational value of novelty is not necessarily based on actual reward-predicting stimulus properties.
科研通智能强力驱动
Strongly Powered by AbleSci AI