小岛
炎症
TLR4型
番茄红素
链脲佐菌素
细胞凋亡
胰岛素抵抗
化学
葡萄糖稳态
二甲双胍
胰岛素
糖尿病
医学
内科学
内分泌学
抗氧化剂
生物化学
作者
Yage Liu,Yimiao Tian,Xuan Dai,Tianyuan Liu,Yueyi Zhang,Shan Wang,Hanfen Shi,Jiyuan Yin,Tianshu Xu,Ruyuan Zhu,Yanfei Zhang,Dandan Zhao,Gao S,Li Wang,Li Wang,Dongwei Zhang
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:14 (11): 5090-5104
被引量:7
摘要
The inflammation of the pancreatic islets triggers β cell dysfunction and type 2 diabetes mellitus (T2DM) onset. While dietary lycopene consumption contributes to protection against T2DM in animal studies, the potential mechanism of this compound in the regulation of islet function in T2DM remains largely unclear. In this study, by using anti-diabetic metformin as a positive control, we demonstrated that lycopene treatment suppressed islet inflammation and apoptosis in both high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic mice and in Min6 cells exposed to high glucose/palmitic acid (HG/PA)-RAW264.7 conditioned medium. Lycopene intervention resulted in M1/M2 macrophage polarization homeostasis, which is associated with increased insulin secretion, decreased fasting blood glucose levels, and improved lipid profiles in diabetic mice. Furthermore, the protective actions of lycopene were associated with the down-regulation of the TLR4/MyD88/NF-κB signaling pathway, which is positively related to inflammation in both diabetic mice and Min6 cells. Collectively, our findings indicated that lycopene ameliorates islet function and apoptosis and attenuates hyperglycemia and dyslipidemia by the regulation of the TLR4/MyD88/NF-κB signaling pathway. This study highlights dietary lycopene consumption as a novel strategy for the management of patients with diabetes.
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