Glucose–Insulin–Potassium Therapy for Acute Myocardial Infarction: 50 Years On and Time for a Relook

HomeCirculationVol. 146, No. 7Glucose–Insulin–Potassium Therapy for Acute Myocardial Infarction: 50 Years On and Time for a Relook No AccessArticle CommentaryRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessArticle CommentaryRequest AccessFull TextGlucose–Insulin–Potassium Therapy for Acute Myocardial Infarction: 50 Years On and Time for a Relook James E. Udelson, MD, Harry P. Selker, MD, MSPH and Eugene Braunwald, MD James E. UdelsonJames E. Udelson Correspondence to: James E. Udelson, MD, Box 70 Cardiology, Tufts Medical Center, 800 Washington St, Boston, MA 02111. Email E-mail Address: [email protected] https://orcid.org/0000-0003-2998-910X Division of Cardiology, the CardioVascular Center (J.E.U.), Tufts Medical Center, Boston, MA. Search for more papers by this author , Harry P. SelkerHarry P. Selker https://orcid.org/0000-0001-5322-7178 Institute for Clinical Research and Health Policy Studies and the Department of Medicine (H.P.S.), Tufts Medical Center, Boston, MA. Search for more papers by this author and Eugene BraunwaldEugene Braunwald https://orcid.org/0000-0002-3472-626X TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (E.B.). Search for more papers by this author Originally published15 Aug 2022https://doi.org/10.1161/CIRCULATIONAHA.121.058740Circulation. 2022;146:503–505FootnotesCirculation is available at www.ahajournals.org/journal/circThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Sources of Funding and Disclosures, see page 505.Correspondence to: James E. Udelson, MD, Box 70 Cardiology, Tufts Medical Center, 800 Washington St, Boston, MA 02111. Email [email protected]orgReferences1. Menees DS, Peterson ED, Wang Y, Curtis JP, Messenger JC, Rumsfeld JS, Gurm HS. Door-to-balloon time and mortality among patients undergoing primary PCI.N Engl J Med. 2013; 369:901–909. doi: 10.1056/NEJMoa1208200CrossrefMedlineGoogle Scholar2. Maroko PR, Libby P, Sobel BE, Bloor CM, Sybers HD, Shell WE, Covell JW, Braunwald E. Effect of glucose-insulin-potassium infusion on myocardial infarction following experimental coronary artery occlusion.Circulation. 1972; 45:1160–1175. doi: 10.1161/01.cir.45.6.1160LinkGoogle Scholar3. Grossman AN, Opie LH, Beshansky JR, Ingwall JS, Rackley CE, Selker HP. Glucose-insulin-potassium revived: current status in acute coronary syndromes and the energy-depleted heart.Circulation. 2013; 127:1040–1048. doi: 10.1161/CIRCULATIONAHA.112.130625LinkGoogle Scholar4. Selker HP, Beshansky JR, Sheehan PR, Massaro JM, Griffith JL, D’Agostino RB, Ruthazer R, Atkins JM, Sayah AJ, Levy MK, et al. Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial.JAMA. 2012; 307:1925–1933. doi: 10.1001/jama.2012.426CrossrefMedlineGoogle Scholar5. Selker HP, Udelson JE, Ruthazer R, D’Agostino RB, Nichols M, Ben-Yehuda O, Eitel I, Granger CB, Jenkins P, Maehara A, et al. Relationship between therapeutic effects on infarct size in acute myocardial infarction and therapeutic effects on 1-year outcomes: a patient-level analysis of randomized clinical trials.Am Heart J. 2017; 188:18–25. doi: 10.1016/j.ahj.2017.02.028CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails August 16, 2022Vol 146, Issue 7 Advertisement Article InformationMetrics © 2022 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.121.058740PMID: 35969651 Originally publishedAugust 15, 2022 Keywordsheart failuremyocardial infarctionPDF download Advertisement SubjectsCardiopulmonary Resuscitation and Emergency Cardiac CareMortality/Survival